specific genes influencing risk of infection, severity of symptoms and death: rs10774671 G is a common variant that exists in both Africans and Europeans before Europeans mated with Neanderthals. Its protective effect (23% reduced risk of critical illness from SARS-COV-2 infection, and virus susceptibility in general) is thought to result due to its interaction with the OAS1 gene (which is part of a cluster largely inherited from Neanderthals), coding for a protein that more effectively breaks down SARS-COV-2. This allele in the gene rs10774671 also protects people of African descent against COVID-19 hospitalization–independently of other associated alleles in that population. Question: What does it mean to “co-segregate with different variants when they are derived from gene flow from Neanderthals”?
[Sexes?: The symptoms of smell and taste loss are linked to UGT2A1 and UGT2A2 on chromosome 4, but for which they have no explanation, although they think the chemical pathways signaling taste/smell are either under- or over-stimulated, reducing or overwhelming the ability to taste and smell. Women are 11 times more likely to be impacted, suggesting perhaps something on the X chromosome or resulting from female physiology is impacted by COVID-19 and is interacting with something on UGT2A1 and/or UGT2A2 (author’s conjecture).]
[Messenger RNA usually originates in (is no stranger to) the nucleus…no? Perhaps that is neither here, nor there.]
¿Race is to ethnicity as sex is to gender? What if we say it like this: ¿Blended race is to race as intersex is to sex? Blending sexes (intersex) has biological consequences that blending races does not. Given that, it is interesting that these days people are less forgiving when a white person claims to be another race than when someone does not identify as their biological sex. Does that imply we are more racist than sexist, or are there better words for that?